In the digital age, Nigerian SMEs have unique opportunities to thrive in e-commerce as we approach 2025. To succeed, businesses should establish a comprehensive online presence by creating user-friendly websites, optimizing for SEO, and engaging through content. Leveraging social media marketing and adopting a multichannel selling approach—utilizing marketplaces and social commerce—is crucial. Exceptional customer service, efficient logistics, and diverse e-payment options enhance customer satisfaction. Additionally, data analytics can provide insights for personalized marketing. By implementing these strategies, SMEs can navigate the evolving e-commerce landscape effectively and capitalize on the growing online shopping trend in Nigeria.